Mesenteric lipodystrophy (ML) is a rare condition characterized by a nonspe
cific inflammatory process that involves the root of the mesentery in a lip
oma-like lesion. Presenting features of ML include abdominal pain, weight l
oss, nausea, vomiting, diarrhea, and constipation. This case illustrates th
at ML should be included in the differential diagnosis of patients with fev
er of unknown origin and mesenteric calcifications.