H. Kusama et al., Cope rearrangement of Delta(3,8)-taxane tricarbocycles: Remarkable solventeffect on product distribution., TETRAHEDR L, 40(22), 1999, pp. 4235-4238
Cope rearrangement of the taxane-like tricyclic compounds having a 1,5-dien
e moiety readily takes place to give novel spirocyclic compounds, This tran
sformation is found to be reversible and the product distribution is greatl
y dependent on the solvent polarity: the reactions in chloroform afford the
taxane-like tricarbocycles, while those in methanol give the spirocyclic c
ompounds exclusively. (C) 1999 Elsevier Science Ltd. All rights reserved.