Practical synthesis of fully-substituted peptide thiazoles

Authors
Buchanan, JL Mani, UN Plake, HR Holt, DA
Citation
Jl. Buchanan et al., Practical synthesis of fully-substituted peptide thiazoles, TETRAHEDR L, 40(21), 1999, pp. 3985-3988
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
21
Year of publication
1999
Pages
3985 - 3988
Database
ISI
SICI code
0040-4039(19990521)40:21<3985:PSOFPT>2.0.ZU;2-Z
Abstract
The synthesis of optically active 2,4,5-substituted 1,3-thiazoles (peptide thiazoles) is described. Both the chirality and the set of side chain funct ionality in this fully-substituted scaffold are derived from a combination of two amino acids and one organometallic reagent. Preliminary results, wit h two specific examples, highlight the potential of this strategy for the p reparation of a diverse set of building blocks, (C) 1999 Elsevier Science L td. All rights reserved.