A simple and concise synthesis of LY231514 (MTA)

Authors
Taylor, EC Liu, B
Citation
Ec. Taylor et B. Liu, A simple and concise synthesis of LY231514 (MTA), TETRAHEDR L, 40(21), 1999, pp. 4023-4026
Citations number
33
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
21
Year of publication
1999
Pages
4023 - 4026
Database
ISI
SICI code
0040-4039(19990521)40:21<4023:ASACSO>2.0.ZU;2-0
Abstract
The pyrrolo[2,3-(d) under bar]pyrimidine anticancer agent LY231514 (MTA, 1) has been prepared utilizing, as a key sequence, Michael condensation of 2, 6-diamino-4(3 (H) under bar)-pyrimidinone (as the donor) with the nitro ole fin 8, followed by a Nef reaction that leads to the annulated pyrrole ring of 1. (C) 1999 Elsevier Science Ltd. All rights reserved.