Stereoselective synthesis of unsaturated very long chain fatty acid methylesters

Authors
Defretin, J Saez, J Franck, X Hocquemiller, R Figadere, B
Citation
J. Defretin et al., Stereoselective synthesis of unsaturated very long chain fatty acid methylesters, TETRAHEDR L, 40(21), 1999, pp. 4041-4044
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
21
Year of publication
1999
Pages
4041 - 4044
Database
ISI
SICI code
0040-4039(19990521)40:21<4041:SSOUVL>2.0.ZU;2-R
Abstract
:Very long chain fatty acids are isolated from many different natural sourc es. However their unsaturated and particularly their diunsaturated derivati ves with a Delta(n,n+4) pattern are almost exclusively encountered in marin e organisms, until we found some derivatives in the botanical family of the Annonaceae. In this letter we present a very efficient synthesis of this f amily of products based on the new transition metal-catalyzed coupling reac tion between an organomagnesium reagent and a functionalized vinyl bromide. (C) 1999 Elsevier Science Ltd. All rights reserved.