A second-generation cycloaddition approach to 3-acyl-4-hydroxypyridin-2-ones

Authors
Jones, RCF Dawson, CE O'Mahony, MJ Patel, P
Citation
Rcf. Jones et al., A second-generation cycloaddition approach to 3-acyl-4-hydroxypyridin-2-ones, TETRAHEDR L, 40(21), 1999, pp. 4085-4088
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
21
Year of publication
1999
Pages
4085 - 4088
Database
ISI
SICI code
0040-4039(19990521)40:21<4085:ASCAT3>2.0.ZU;2-9
Abstract
The 1,3-dipolar cycloaddition of the beta-aminonitrile oxide, formed from b eta-alanine, to the enamine of a beta-ketoester affords a 3-(2-aminoalkyl)i soxazole-4-carboxylic eater that is converted via isoxazolo[4,5-c]pyridin-4 -ones into 3-acetyl-4-hydroxypyridin-2-ones. (C) 1999 Elsevier Science Ltd. All rights reserved.