DNA chips: promising toys have become powerful tools

Authors
Gerhold, D Rushmore, T Caskey, CT
Citation
D. Gerhold et al., DNA chips: promising toys have become powerful tools, TRENDS BIOC, 24(5), 1999, pp. 168-173
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
24
Issue
5
Year of publication
1999
Pages
168 - 173
Database
ISI
SICI code
0968-0004(199905)24:5<168:DCPTHB>2.0.ZU;2-5
Abstract
DNA chips are glass surfaces that represent thousands of DNA fragments arra yed at discrete sites. Hybridization of RNA or DNA-derived samples to DNA c hips allows us to monitor expression of mRNAs or the occurrence of polymorp hisms in genomic DNA. The technology holds great promise for identifying ge ne polymorphisms that predispose man to disease, gene regulation events inv olved in disease progression, and more-effective disease treatments.