Interaction of deoxyribo-oligonucleotides with divalent manganese ions: comparison of vibrational circular dichroism and absorption spectroscopy

Authors
Andrushchenko, VV van de Sande, JH Wieser, H
Citation
Vv. Andrushchenko et al., Interaction of deoxyribo-oligonucleotides with divalent manganese ions: comparison of vibrational circular dichroism and absorption spectroscopy, VIB SPECTR, 19(2), 1999, pp. 341-345
Citations number
17
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
VIBRATIONAL SPECTROSCOPY
ISSN journal
09242031 → ACNP
Volume
19
Issue
2
Year of publication
1999
Pages
341 - 345
Database
ISI
SICI code
0924-2031(199904)19:2<341:IODWDM>2.0.ZU;2-V
Abstract
Vibrational circular dichroism (VCD) spectra are reported for d(GC)(20). d( GC)(20) and d(ATGCATGCAT). d(ATGCATGCAT) in D2O without Mn2+ and in the pre sence of 0.64 and 0.50 [Mn]/[P] concentration ratios, respectively. Changes in the VCD spectra are compared with the changes of the corresponding infr ared absorption bands and interpreted in terms of structural changes in the oligonucleotides. Based on these examples, it appears that VCD provides be tter definition of structural modification as a result of complexation with Mn2+ ions than infrared absorption. (C) 1999 Elsevier Science B.V. All rig hts reserved.