Modulation of oxidative stress in human skin of old donors

Oxidative stress (UV irradiation, free radicals) plays a significant role i n aging. Coenzyme Q10 (CoQ10) and exogenously applied antioxidants can sign ificantly reduce the formation of oxidative stress with increasing age. In our in vitro and in vivo experiments concerning the parameters of ultraw eak photon emission (UPE), intracellular thiol status, mitochondrial membra ne potential and cell vitality, we demonstrated a diminished resistance in keratinocytes of old donors against UV irradiation. This reduced epidermal resistance against oxidative stressors, i.e. UV irradiation, can be improve d by topical application of CoQ10 and antioxidants like alpha-glucosylrutin (15). Furthermore, our in vivo investigations show that wrinkles around th e region of the eyes ("crow feet") could be reduced by long-term applicatio n of CoQ10.