Clinical laboratory diagnostics and aging. Part 1: Results of the data evaluation of clinical chemical analytes in an aging study

compared between both groups, are significantly different: Urea, uric acid, creatinine, triglycerides, total cholesterol, LDL cholesterol, LDL-C/HDL-C ratio, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl tran sferase, sodium and ferritin are increased in the older group, whereas HDL cholesterol, iron, transferrin, and total protein are decreased. The sex di fferences are more distinct in the group of 44 years old persons than in th e 63 years old one. These results will be completed by the comparison with the evaluation of the stored laboratory values of 9923 patients between 20 and 89 years old. The results of the determination of 24 basic blood chemis try variables from 262 men and 239 women, half of each group 44.4 +/- 0.9 a nd 63.0 +/- 0.9 (men) and 44.4 +/- 0.9 and 62.8 +/- 0.8 years old (women), resp., are compared. In men, only 6 analytes show significant differences b etween the age groups: Alanine aminotransferase down arrow, aspartate amino transferase down arrow, iron down arrow with p < 0.05; sodium down arrow, c alcium down arrow, protein (serum) down arrow with p < 0.001. In women, 16 analytes, compared between both groups, are significantly different: Urea, uric acid, creatinine, triglycerides, total cholesterol, LDL cholesterol, L DL-C/HDL-C ratio, alanine aminotransferase, alkaline phosphatase, gamma-glu tamyl transferase, sodium and ferritin are increased in the older group, wh ereas HDL cholesterol, iron, transferrin, and total protein are decreased. The sex differences are more distinct in the group of 44 years old persons than in the 63 years old one. These results will be completed by the compar ison with the evaluation of the stored laboratory values of 9923 patients b etween 20 and 89 years old.