Aims. in an additive design, test the efficacy of cue exposure treatment fo
r smoking relapse prevention as an adjunct to current standard cognitive be
havioral and pharmacological treatments. Design. Randomized, controlled cli
nical trial. Setting. Outpatient behavioral medicine clinic. Participants.
One hundred and twenty-nine cigarette smokers recruited through newspaper a
dvertisements. Intervention. After receiving an initial counseling session
for cessation and setting a quit day, 129 smokers were randomly assigned to
one of four relapse prevention treatment conditions: (1) brief cognitive b
ehavioral; (2) cognitive behavioral and nicorette gum; (3) cognitive behavi
oral and cue exposure; and (4) cognitive behavioral and cue exposure with n
icorette gum. All smokers met individually with their counselor for six RP
sessions. Measures. Seven-day, point-prevalence abstinence rates (CO verifi
ed) taken at 1, 3, 6 and 12-months post-treatment and time to first slip. F
indings. All manipulation checks and process measures suggested that the tr
eatments were delivered as intended. There were no significant differences
between conditions in point-prevalence abstinence rates or in time to first
slip. Conclusions. These results call into question the utility of cue exp
osure treatment for smoking relapse prevention.