Strategies for mucosal vaccine development

Citation
Pn. Boyaka et al., Strategies for mucosal vaccine development, AM J TROP M, 60(4), 1999, pp. 35-45
Citations number
117
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
60
Issue
4
Year of publication
1999
Supplement
S
Pages
35 - 45
Database
ISI
SICI code
0002-9637(199904)60:4<35:SFMVD>2.0.ZU;2-R
Abstract
Vaccines able to induce both secretory IgA for protection of mucosal surfac es and systemic immunity to pathogens invading the host are of great intere st in the war against infectious diseases. Mucosal vaccines trigger immune cells in mucosal inductive sites and thus can induce immunity in both the m ucosal and systemic compartments. This review presents a critical survey of adjuvants and delivery systems currently being tested for mucosal immuniza tion. A better understanding of cellular and molecular factors involved in the regulation of mucosal immunity will help in the design of safer mucosal vaccines to elicit the appropriate protective immune response to a given p athogen.