Preparation of [Re-186]Re-DMSA and its bio-distribution studies

Tc-99m(V)-DMSA is widely used for imaging medullary carcinoma and hence Re- 186/188(V)-DMSA is suggested as a potential agent for treating medullary ca rcinoma. In the present paper, we report the work carried out for the prepa ration of [Re-186]Re(V)-DMSA and it's bio-distribution studies in Wister ra ts, The complex was prepared by reducing Re-186 (100 mu g, 0.54 mu M, simil ar to 150 MBq) in the presence of DMSA (2 mg, 11 mu M) with stannous chlori de (0.4 mg, 2.2 mu M) in acidic medium at pH 2, The reaction was taken to c ompletion by heating the complex in a boiling water bath for 30 min. Bio-di stribution studies carried out revealed that pharmacological behaviour of R e-186(V)-DMSA is similar to that of Tc-99m(V)-DMSA except that the kidney u ptake is marginally higher. The kidney uptake reduced significantly when th e pH of the complex was adjusted to 8 prior to injection. The in vitro stab ility studies of this complex suggest that the product formed is stable and could be used for clinical trials. (C) 1999 Elsevier Science Ltd. All righ ts reserved.