1,2-ASYMMETRIC INDUCTION IN THE TICL4 MEDIATED ALKYLATION OF ALPHA-METHYL-BETA-SILYLOXY KETONES WITH GRIGNARD-REAGENTS

Authors
BARTOLI G BOSCO M SAMBRI L MARCANTONI E
Citation
G. Bartoli et al., 1,2-ASYMMETRIC INDUCTION IN THE TICL4 MEDIATED ALKYLATION OF ALPHA-METHYL-BETA-SILYLOXY KETONES WITH GRIGNARD-REAGENTS, Tetrahedron letters, 38(21), 1997, pp. 3785-3788
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
21
Year of publication
1997
Pages
3785 - 3788
Database
ISI
SICI code
0040-4039(1997)38:21<3785:1IITTM>2.0.ZU;2-J
Abstract
Transmetallation of an alpha-methyl-beta-silyloxy ketone with TiCl4 in toluene affords a cyclic chelation complex which undergoes highly ste reoselective alkylation from Grignard reagents at the less hindered si de. (C) 1997 Published by Elsevier Science Ltd.