A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp.

Authors
Nosaka, C Kunimoto, S Masuda, T Ohsono, M Iinuma, H Tsuchida, T Hamada, M Takeuchi, T
Citation
C. Nosaka et al., A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp., BIOL PHAR B, 22(5), 1999, pp. 546-548
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
22
Issue
5
Year of publication
1999
Pages
546 - 548
Database
ISI
SICI code
0918-6158(199905)22:5<546:ANC2CP>2.0.ZU;2-5
Abstract
A new cytotoxic substance was isolated following acid treatment of fermente d broth of a Streptomyces strain numbered MJ915-WF12. The structure was elu cidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydr oxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.