C. Nosaka et al., A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp., BIOL PHAR B, 22(5), 1999, pp. 546-548
A new cytotoxic substance was isolated following acid treatment of fermente
d broth of a Streptomyces strain numbered MJ915-WF12. The structure was elu
cidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydr
oxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration
and ring reformation of the precursor material in cultured broth by acid.