IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS

Authors
Bizzini, B Volpato, I Lachgar, A Cohen, P Gringeri, A
Citation
B. Bizzini et al., IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS, BIOMED PHAR, 53(2), 1999, pp. 87-89
Citations number
21
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOMEDICINE & PHARMACOTHERAPY
ISSN journal
07533322 → ACNP
Volume
53
Issue
2
Year of publication
1999
Pages
87 - 89
Database
ISI
SICI code
0753-3322(199903)53:2<87:IAKVIC>2.0.ZU;2-Y
Abstract
Antiviral therapy, including antiprotease treatment, suppresses viral repli cation, but it does not restore the HIV-1 induced immunopathogenesis which includes IFN alpha overproduction and cellular immunosuppression. To combat HIV-1 induced immunopathogenesis, anti-IFN alpha kinoid immunization in co mbination with tritherapy may be beneficial to HIV-1 infected immunodeficie nt patients. (C) 1999 Elsevier, Paris.