Hb. Nader et al., Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?, BRAZ J MED, 32(5), 1999, pp. 529-538
Citations number
45
Categorie Soggetti
Medical Research General Topics
Journal title
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
The distribution and structure of heparan sulfate and heparin are briefly r
eviewed. Heparan sulfate is a ubiquitous compound of animal cells whose str
ucture has been maintained throughout evolution, showing an enormous variab
ility regarding the relative amounts of its disaccharide units. Heparin, on
the other hand, is present only in a few tissues and species of the animal
kingdom and in the form of granules inside organelles in the cytoplasm of
special cells. Thus, the distribution as well as the main structural featur
es of the molecule, including its main disaccharide unit, have been maintai
ned through evolution. These and other studies led to the proposal that hep
aran sulfate may be involved in the cell-cell recognition phenomena and con
trol of cell growth, whereas heparin may be involved in defense mechanisms
against bacteria and other foreign materials. All indications obtained thus
far suggest that these molecules perform the same functions in vertebrates
and invertebrates.