Pws. Heng et al., A new method for the control of size of pellets in the melt pelletization process with a high shear mixer, CHEM PHARM, 47(5), 1999, pp. 633-638
The control of the melt pelletization process in an 8-1 high shear miser us
ing specific energy consumption of the impeller motor was studied. Lactose
was used as the bulk material with polyethylene glycol 3000 as a meltable b
inder. The effects of binder concentration, mean particle size of bulk mate
rial and post-melt impeller speed on the relationship of specific energy co
nsumption and pellet growth were examined. Specific energy consumption was
found to be a suitable tool for monitoring the melt pelletization process,
and specific energy consumption correlated well with pellet growth. The mea
n size of the pellets formed becomes correspondingly larger with increasing
specific energy consumption. Concerning the impeller speed, specific energ
y consumption is more useful as a tool for end-point control of the process
than post-melt mixing time. Similar size pellets can be obtained with comp
arable specific energy consumption, independent of the impeller speed. The
control of pellet size requires a correlation between pellet growth and spe
cific energy consumption that is established for the formulation and proces
s conditions used, For this purpose, mathematical modelling of the pellet g
rowth process is presented. The predictions of pellet growth by the mathema
tical model are in agreement with the experimental findings.