Unexpected catalytic behavior of chiral bisoxazoline in asymmetric reaction of lithium ester enolate with imine

Authors
Kambara, T Tomioka, K
Citation
T. Kambara et K. Tomioka, Unexpected catalytic behavior of chiral bisoxazoline in asymmetric reaction of lithium ester enolate with imine, CHEM PHARM, 47(5), 1999, pp. 720-721
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
5
Year of publication
1999
Pages
720 - 721
Database
ISI
SICI code
0009-2363(199905)47:5<720:UCBOCB>2.0.ZU;2-V
Abstract
Reaction of a lithium ester enolate with benzaldehyde anisidine-imine was c atalyzed by a catalytic amount of bisoxazoline ligand to afford the corresp onding beta-lactam in higher ee than that obtained by the reaction using a stoichiometric amount of the ligand. Investigation of the varying factors s uggested the involvement of steric factors.