Insulin action in thee polycystic ovary syndrome

Authors
Dunaif, A
Citation
A. Dunaif, Insulin action in thee polycystic ovary syndrome, END METAB C, 28(2), 1999, pp. 341
Citations number
57
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
ISSN journal
08898529 → ACNP
Volume
28
Issue
2
Year of publication
1999
Database
ISI
SICI code
0889-8529(199906)28:2<341:IAITPO>2.0.ZU;2-5
Abstract
Polycystic ovary syndrome is associated with profound insulin resistance, c onferring an approximately 7-fold increased risk for type 2 diabetes mellit us in premenopausal women. The mechanisms of insulin resistance in PCOS are distinct from those in obesity and in typical type 2 diabetes mellitus. Th ere also is evidence for pancreatic beta-cell dysfunction in PCOS that can occur independent of obesity and glucose intolerance. Insulin resistance co ntributes to the reproductive abnormalities of PCOS.