Pilot study on the treatment of cyclical mastodynia with Quinagolide

Citation
L. Ioannidou-mouzaka et al., Pilot study on the treatment of cyclical mastodynia with Quinagolide, EUR J GYN O, 20(2), 1999, pp. 117-121
Citations number
39
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
ISSN journal
03922936 → ACNP
Volume
20
Issue
2
Year of publication
1999
Pages
117 - 121
Database
ISI
SICI code
0392-2936(1999)20:2<117:PSOTTO>2.0.ZU;2-E
Abstract
In a pilot clinical trial on 52 patients, 75 mu g Quinagolide given once pe r day was administered for the treatment of cyclical mastodynia. Linear ana logue charts were used for the assessment of response. Decrease in breast p ain, heaviness, tenderness and serum prolactin level on the one hand, and i ncreases in the serum estradiol and progesterone levels on the other hand w ere noted after 3 and 6 months administration, and were statistically signi ficant. Statistical analysis was performed by Paired t-test or Wilcoxon tes t, One-Way Anova Repeated Measures and Wilcoxon test and analysis of Covari ance model. The beneficial effect of Quinagolide also lasted after the cess ation of treatment. Fourteen patients dropped out during treatment. Adverse effects like nausea, low blood pressure, dizziness and constipation were r arely reported.