4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase

Authors
Howes, PD Cleasby, A Evans, DN Feilden, H Smith, PW Sollis, SL Taylor, N Wonacott, AJ
Citation
Pd. Howes et al., 4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase, EUR J MED C, 34(3), 1999, pp. 225-234
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
3
Year of publication
1999
Pages
225 - 234
Database
ISI
SICI code
0223-5234(199903)34:3<225:4AANIO>2.0.ZU;2-9
Abstract
Two methods for the synthesis of 4-acetylamino benzoic acids substituted at the 3-position with imidazoles are described. Many of the compounds are in hibitors of influenza virus sialidases with levels of activity similar to t he recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113). (C ) Elsevier, Paris.