2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents

Authors
Goel, B Ram, T Tyagi, R Bansal, E Kumar, A Mukherjee, D Sinha, JN
Citation
B. Goel et al., 2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents, EUR J MED C, 34(3), 1999, pp. 265-269
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
3
Year of publication
1999
Pages
265 - 269
Database
ISI
SICI code
0223-5234(199903)34:3<265:2AP>2.0.ZU;2-G
Abstract
New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl) -5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-i nflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-fluorop henyl)-5-methyl-4-thiazolidinone 6 was compared with phenylbutazone for its relative antiinflammatory potency and ulcerogenic liability. ED50, cardiov ascular and central nervous system effects of 6 were also studied. (C) Else vier, Paris.