Synthesis of some new biologically active thiadiazolotriazinones - Part II

Authors
Holla, BS Sarojini, BK Shridhara, K Antony, G
Citation
Bs. Holla et al., Synthesis of some new biologically active thiadiazolotriazinones - Part II, FARMACO, 54(3), 1999, pp. 149-151
Citations number
3
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
54
Issue
3
Year of publication
1999
Pages
149 - 151
Database
ISI
SICI code
0014-827X(19990331)54:3<149:SOSNBA>2.0.ZU;2-I
Abstract
4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condens ed with an aromatic carboxylic acid, aryloxy-acetic acid or anilinoacetic a cid (2), to yield 7-substituted-3-phenyl/methyl-4H- 1,3,4-thiadiazolo-[2,3- c]-1,2,4-triazin-4-ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial a ctivities against S. aureus, E. coil, P. aeruginosa and G. bacillus. (C) 19 99 Elsevier Science S.A. All rights reserved.