Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones. Part 3

A new series of quinoxalinones 6/7-trifluoromethyl or nitro- and 6,7-difluo ro substituted bearing various side-chains (alkyl, halogenoalkyl, benzyl an d phenyl groups) at C-3 of the ring system was synthesized and submitted to preliminary in vitro evaluation for antibacterial, antifungal, antimycobac terial, anticancer and anti-HIV activities. Results of these screenings sho wed that compounds 23-28 exhibited a good inhibition activity against vario us strains of Candida. Compound 24 showed also an interesting in vitro anti cancer activity. (C) 1999 Elsevier Science S.A. All rights reserved.