Palm vitamin E improves bone metabolism and survival rate in thyrotoxic rats

Citation
S. Ima-nirwana et al., Palm vitamin E improves bone metabolism and survival rate in thyrotoxic rats, GEN PHARM, 32(5), 1999, pp. 621-626
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
GENERAL PHARMACOLOGY
ISSN journal
03063623 → ACNP
Volume
32
Issue
5
Year of publication
1999
Pages
621 - 626
Database
ISI
SICI code
0306-3623(199905)32:5<621:PVEIBM>2.0.ZU;2-D
Abstract
The effects of vitamin E derived from palm oil on bone turnover in thyrotox ic rats were studied. Palm vitamin E reduced bone resorption to a greater e xtent than bone formation in thyrotoxic rats, suggesting a net reduction in bone loss. The action of palm vitamin E is probably due to its antioxidant properties. Survival rates were also significantly increased in thyrotoxic rats given palm vitamin E, suggesting the role of free radicals in the ove rall morbidity and mortality in thyrotoxicosis. (C) 1999 Elsevier Science I nc. All rights reserved.