Total synthesis of (+/-)-deethyleburnamonine and vindeburnol (RU 24722) with the corresponding nitriles as starting material

Authors
Lounasmaa, M Din Belle, D Tolvanen, A
Citation
M. Lounasmaa et al., Total synthesis of (+/-)-deethyleburnamonine and vindeburnol (RU 24722) with the corresponding nitriles as starting material, HETEROCYCLE, 51(5), 1999, pp. 1125-1130
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
5
Year of publication
1999
Pages
1125 - 1130
Database
ISI
SICI code
0385-5414(19990501)51:5<1125:TSO(AV>2.0.ZU;2-5
Abstract
Cyclisation occurred during base treatment of cis-nitrile (5). The resultin g new imine (6) was converted into the therapeutically important deethylebu rnamonine (4). Total synthesis of vindeburnol (RU 24722) (3), another impor tant drug, was achieved in one step starting from the trans-nitrile (9).