Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans

Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycopl asma fermentans were demonstrated to trigger the transcription of intercell ular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gin gival tissue and to induce its cell surface expression by a mechanism disti nct from that of Escherichia call lipopolysaccharide. The lipid moiety of t he lipoproteins was suggested to play a key role in the expression of the a ctivity.