The bone marrow cells radioprotection by amifostine - NN/N ratio, apoptosis, ultrastructural and lipid matrix evaluation

The present experiment was performed in order to estimate the amifostine-WR 2721 (ami) bone marrow cells radioprotection, by the following parameters. NN/N ratio, the apoptotic cell counting, ultrastructural analysis and lipid matrix (membrane) injury evaluation. The protected marrows showed: significant low NN/N ratio (24h); significant low number of apoptotic cells (4,12h); better ultrastructural aspect (4,12 ,24h and 10 days); less lipid matrix injury (4h). These findings show that amifostine is an efficient radioprotector for the bone marrow cells.