Clomipramine treatment of delusional disorder, somatic type

Four patients of delusional disorder, somatic type, were treated with clomi pramine 60-120 mg/day. All patients showed marked clinical improvement afte r 27-57 days of clomipramine treatment. In one case, previous treatments by various antipsychotic drugs including pimozide had been unsuccessful. This report suggests that clomipramine is effective at least for some patients with delusional disorder, somatic type, including pimozide-resistant cases. It is also suggested that there is some association between delusional dis order, somatic type, and serotonergic dysfunction. Int Clin Psychopharmacol 14:181-183 (C) 1999 Lippincott Williams & Wilkins.