The effect of augmentation with moclobemide on symptoms of schizophrenia

The effectiveness of adding moclobemide to antipsychotic treatment in schiz ophrenic patients with prominent negative symptoms was examined. Eleven chr onic schizophrenic patients had their regular antipsychotic treatment augme nted by the addition of moclobemide 450 mg/day for 8 weeks. A significant i mprovement was seen on the Positive and Negative Syndrome Scale (PANSS) neg ative factor and for the Scale for the Assessment of Negative Symptoms (SAN S) scores, PANSS total score, PANSS general factor score and Hamilton Depre ssion Scale scores. Positive symptoms were not altered. Moclobemide augment ation may ameliorate negative, depressive and general symptoms in schizophr enia. Int ain Psychopharmacol 14:193-195 (C) 1999 Lippincott Williams & Wil kins.