Cholecystokinin regulates the invasiveness of human pancreatic cancer celllines via protein kinase C pathway

We have previously reported that cholecystokinin (CCK) plays an important r ole in the invasiveness and the production of matrix metalloproteinase-9 (M MP-9) in two human pancreatic cancer cell lines. In this study we investiga ted the pathway of the invasiveness associated with MMP-9 of those lines re gulated by CCK. Two human pancreatic cancer cell lines were treated with CC K-8 alone, CCK-8 and staurosporine, or CCK-8 and indomethacine. The invasiv eness and the production of MMP-9 were decreased with staurosporine but not indomethacine. These results suggest that CCK may regulate the invasivenes s and the production of MMP-9 via protein kinase C in human pancreatic canc er eel lines.