Endoscopic retrograde cholangiopancreatography (ERCP) is diagnostic. Simila
rly, secretin stimulated ultrasonography may positively predict the outcome
of minor papilla therapy. Computed tomography is only helpful for the dete
ction of complications. Magnetic resonance cholangiopancreatography (MRCP)
is a new noninvasive diagnostic tool in development. It is accurate and mig
ht replace ERCP for diagnosis.
Clinically, symptomatic patients with PD may be divided into five groups: g
roup 1, those with minimal symptoms; group 2, those with recurrent acute pa
ncreatitis or upper abdominal pain with no other cause; group 3, those with
chronic pancreatitis; group 4, those with chronic pancreatic pain; and gro
up 5, those with other complications.
Group 1 should be treated with medical therapy alone. The response to surgi
cal or endoscopic therapy of the minor papilla is good in group 2 (75-90%),
moderate in group 3 (40-60%), and poor in group 4 (20-40%). A few patients
require other forms of pancreatic surgery, such as Puestow's operation, Be
ger's operation, or distal pancreatectomy. With careful selection of patien
t and therapy, good response to the therapy can be achieved.
Pancreas divisum (PD) is the most common congenital anomaly of the pancreas
, with an incidence of up to 10%. Symptoms or complications developing in i
ndividuals with PD are uncommon (5% of individuals with PD). It seems unlik
ely that PD alone could cause obstructive pancreatitis and the presence of
another factor, such as minor papilla insufficiency, is probably required f
or this relatively common anomaly to develop complications.