Duodenal necrosis is a rare, but very serious complication of acute necroti
zing pancreatitis that most likely is the result of vascular compromise and
ischemia of the peri-Vaterian aspect of the duodenal wall. In this article
, we present three patients with duodenal necrosis complicating acute necro
tizing pancreatitis. The diagnosis was made at the time of necrosectomy. Ma
nagement options of this challenging complication of necrotizing pancreatit
is are discussed.