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In a study evaluating naltrexone with either an intensive psychosocial
protocol or standard community treatment for opioid dependence, 13 of
81 subjects overdosed within a 12-month period of study participation
. There were four fatalities, one of which was a suicide. Among the ni
ne nonfatal overdoses, there were four suicide attempts. Characteristi
cs of subjects and naltrexone-taking are described. (C) 1997 Elsevier
Science Ireland Ltd.