The cause of eyelid pruritus (itching) may be difficult to determine, parti
cularly in preverbal children. Tearing, photophobia, or eye rubbing may be
the first manifestation of leukemic infiltration or graft-versus-host disea
se, necessitating early appropriate therapy.(1) We report a child in whom p
ersistent eye rubbing developed after bone marrow transplantation for leuke
mia. Morphine administration was found to be the cause of this symptom.