Cryptococcal osteomyelitis of the spine

We have treated seven patients with cryptococcal spondylitis, Five presente d with a neurological deficit and one was HIV-positive. Amphotericin-B and 5-flucytosine were used in five patients and ketoconazole was given orally in the remaining two. Three patients made a complete neurological recovery. Since these lesions mimic spinal tuberculosis, which is commonly seen in o ur environment, we draw attention to the importance of obtaining a tissue d iagnosis.