A seizure warning device might allow some individuals with partial seizures
to protect themselves against consequences of seizures, but a prerequisite
is the ability to take volitional action in response to a warning. The aut
hors reviewed consecutive seizures in their epilepsy monitoring unit to det
ermine whether patients could squeeze an event bulb, as instructed, at the
start of their seizure. Only complex partial seizures with EEG changes and
with the patient on camera were analyzed. Data were obtained from 77 patien
ts, 42 with scalp monitoring and 35 with depth electrodes. Forty-seven perc
ent had a left-hemisphere focus, 42% a right-hemisphere focus, and 11% mult
ifocal seizures. The seizure focus was temporal in 68%. A magnetic resonanc
e imaging consistent with mesial temporal sclerosis was seen in 29% of pati
ents. Overall, 44% of the patients made at least one attempt to reach for t
he event bulb at the start of their seizures. Among the 72% of patients who
gave a history of auras, 53% were able to press the event bulb compared to
20% with no history of auras (P = 0.016). EEG changes occurred a mean of 2
.9 +/- 30.5 seconds after reaching for the bulb for scalp-recorded seizures
(n = 20), and 16.2 +/- 13.7 seconds before behavior for depth-recorded sei
zures (n = 14, difference significant at P = 0.02). Neither seizure focus n
or seizure laterality influenced the ability to press the event bulb. The a
uthors conclude that nearly half of individuals with complex partial seizur
es can take volitional motor action at the start of their seizure. A method
to enhance the intensity and timeliness of a seizure warning would not be
wasted.