The rise and integration of the regional level in the European Union (EU) m
ulti-level system threatens to overload policy-making owing to a rising num
ber of actors, levels and different institutional settings. Based on compar
ative empirical research on different types of region (less developed regio
ns vs. city-regions) in both France and Germany, it is argued that adjustme
nts of both intergovernmental and regional structures lead to the developme
nt of a multi-level framework in which dangers of overload and malfunctions
can be successfully circumvented. Concerning the intergovernmental dimensi
on of regional development policies, it is shown that the dynamic different
iation of decision-making structures as well as a balanced mixture of diffe
rent modes of governance (co-operative networks, hierarchy and competition)
can provide viable escape routes from potential deadlock. However, process
es of structuring multi-level governance depend to a considerable degree on
the national institutional setting which may provide favourable conditions
for processes of adaptation, but may also impede them.