Anti-neutrophil cytoplasmic antibody-associated mucocutaneous allergic vasculitis with oral manifestations caused by propylthiouracil

A 49-year-old woman treated with increasing dosage of propylthiouracil (PTU ) in order to control hyperthyroidism, developed progressive necrotic ulcer s in the oral cavity, oropharynx and rhinopharynx and vasculitic ulcers on both auricular pinnae after a few days. The PTU treatment was immediately d iscontinued and the mucosal and skin manifestations resolved promptly. Labo ratory findings, including anti-neutrophil cytoplasmic antibodies (ANCA), s uggested allergic vasculitis. This is to din knowledge the first reported c ase of oral manifestations of PTU-induced allergic vasculitis.