Peptide and glycopeptide dendrimers. Part II

Recent progress in peptide and glycopeptide chemistry make the preparation of peptide and glycopeptide dendrimers of acceptable purity, with designed structural and immunochemical properties reliable. New methodologies using unprotected peptide building blocks have been developed to further increase the possibilities of their design and improve their preparation and separa tion. The sophisticated design of peptide and glycopeptide dendrimers has l ed to their use as antigens and immunogens, for serodiagnosis and other bio chemical uses including drug delivery. Dendrimers bearing peptide with pred etermined secondary structures are useful tools in protein de novo design. This article covers synthesis and applications of multiple antigen peptides (MAPs), multiple antigen glycopeptides (MAGs), multiple antigen peptides b ased on sequential oligopeptide carriers (MAP-SOCs), glycodendrimers and te mplate-assembled synthetic proteins (TASPs). In part II the preparation of MAPs, and the utility of glycodendrimers and TASPs are discussed. Copyright (C) 1999 European Peptide Society and John Wiley & Sons, Ltd.