Hydrogen bonding interactions between Starburst dendrimers and several molecules of biological interest

H-1 NMR spectroscopy was used to analyze the interactions between poly(amid oamine) (PAMAM) Starburst dendrimers (SBDs) 1-4 and several biologically im portant guests (pyridine, quinoline, quinazoline, nicotine and trimethadion e). Association constants obtained from changes in the chemical shifts of t he amide protons in the host indicate two different interaction sites insid e and on the periphery of the dendrimer. Binding at the inner site is inhib ited in the ester-terminated dendrimers. Copyright (C) 1998 John Wiley & So ns, Ltd.