Influence of donor factors on early function of graft kidneys

Factors which influence graft function can be divided into donor factors th at affect both kidneys from the same donor equally and postdonor factors th at affect each kidney individually. This study assessed the influence of do nor factors on graft function early after transplantation. Sixty-one donors who provided kidneys that were transplanted locally into two separate reci pients were identified. Recipient creatinine clearance values were estimate d from serum creatinine concentrations using a computer model. Pairwise ANO VA showed that donor factors accounted for 35 to 45% of the variation in re cipient creatinine clearance from 2 d to 2 wk posttransplantation. Although donor factors had a large aggregate effect during this period, individual factors that influenced graft function could not be identified from analysi s of donor medical records. At 6 mo after transplantation: the effect of do nor factors on graft function was no longer discernible. These results show that the condition of the donor exerts an important influence on graft fun ction early after transplantation. More detailed study is required to ident ify individual factors that contribute to this effect.