Adult de novo acute myeloid leukemias with MLL rearrangements

Authors
Bellido, MD Nomdedeu, JF
Citation
Md. Bellido et Jf. Nomdedeu, Adult de novo acute myeloid leukemias with MLL rearrangements, LEUK RES, 23(6), 1999, pp. 585-588
Citations number
10
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
23
Issue
6
Year of publication
1999
Pages
585 - 588
Database
ISI
SICI code
0145-2126(199906)23:6<585:ADNAML>2.0.ZU;2-2
Abstract
MLL gene rearrangements identify a subgroup of acute leukemias with a bad p rognosis. Fifty-one adult patients with de novo AML were screened for MLL r earrangements by Southern blot. An unexpected high frequency of AML-MZ acco rding to the FAB classification was found. The most striking morphologic fe atures of these cases were the scarcity of Auer rods and granulocytic dyspl asia. Morphologic traits could be helpful in distinguishing molecular group s of AML-M2. (C) 1999 Elsevier Science Ltd. All rights reserved.