Application of automation and thermal analysis to resolving agent selection

The use of differential scanning calorimetry as a means to identify diaster eoisomeric salts with a clear eutectic composition that is needed for effec tive resolution is described and forms the basis of a resolving agent scree ning process. Automated salt synthesis using an Advanced ChemTech robot is also described. Rapid data analysis is facilitated using an in-house softwa re package, Resolution Companion, which also enables identification of the optimum crystallization conditions following a trial crystallization experi ment.