Lifestyle and biologic contributors to proximal femur bone mineral densityand hip axis length in two distinct ethnic groups of premenopausal women

Citation
Dl. Alekel et al., Lifestyle and biologic contributors to proximal femur bone mineral densityand hip axis length in two distinct ethnic groups of premenopausal women, OSTEOPOR IN, 9(4), 1999, pp. 327-338
Citations number
48
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
OSTEOPOROSIS INTERNATIONAL
ISSN journal
0937941X → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
327 - 338
Database
ISI
SICI code
0937-941X(1999)9:4<327:LABCTP>2.0.ZU;2-C
Abstract
Although relatively little is known about osteoporotic risk factors in wome n from the Indian subcontinent, osteoporotic fractures usually occur 10-20 years earlier in Indian men and women compared with their western Caucasian counterparts. The primary purpose of this cross-sectional study was to det ermine the relative contributions of ethnicity, reproductive history, body size (height, weight) and composition, bone turnover, serum 25(OH)vitamin D -3 [25(OH)D-3], dietary intake (of calcium, fiber and alcohol) and energy e xpenditure to femoral bone mineral density (BMD) in Indian and Pakistani (I ndian/Pakistani; n = 47) versus American (n = 47) Caucasians. We also contr asted femoral BMD and hip axis length in these two distinct groups of preme nopausal females living in the USA. The Indian/Pakistani (0.875 +/- 0.096) women had lower (p = 0.0014) femoral BMD (g/cm(2)) than their American (0.9 37 +/- 0.088) counterparts, placing them at greater osteoporotic risk. Howe ver, the shorter (p = 0.0002) hip axis length (cm) of the Indian/Pakistani (10.54 +/- 0.57) versus American (11.11 +/- 0.78) Caucasians might attenuat e hip fracture risk in the former group. Significant contributors to proxim al femur BMD were maximum non-pregnant lifetime weight, age at menarche, ra tio of Sigma central-to-peripheral skinfold thicknesses, calcium intake fro m milk and usual alcohol intake. Although serum 25(OH)D-3 and urinary N-tel opeptide concentrations did not contribute to femoral BMD in the regression models, the lower (p <0.0001) serum 25(OH)D3 (33.1 +/- 16.5 vs 64.0 +/- 22 .0 nmol/l) and higher (p = 0.0004) urinary N-telopeptide (45.9 +/- 43.3 vs 18.9 +/- 18.7 nmol BCE/mmol) values in Indian/Pakistani versus American Cau casians, respectively, coupled with their lower BMD, places the Indian/Paki stani women at greater osteoporotic risk. These results suggest that a clin ical trial to increase BMD and reduce osteoporotic risk is warranted in thi s ethnic group of premenopausal women.