Synthesis of heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anticancer drugs: part I

Some new heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety (3-22) have been achieved by treatment of 3-amino-5,6-disubstituted-1,2,4-t riazines 2a-h with some cyclic and acyclic oxygen compounds followed by het erocyclization. Structures of the products have been deduced by elemental a nalysis and spectral data. Significant anti-HIV and anticancer activities w ere observed in vitro for some members of the series, where compounds 5 and 18 showed a moderate activity.