Synthesis and immunological activity of new 5-amino-3-methyl 4-amido and 4-ureilene isoxazole derivatives

Authors
Ryng, S Machon, Z Wieczorek, Z Zimecki, M
Citation
S. Ryng et al., Synthesis and immunological activity of new 5-amino-3-methyl 4-amido and 4-ureilene isoxazole derivatives, PHARMAZIE, 54(5), 1999, pp. 359-361
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
5
Year of publication
1999
Pages
359 - 361
Database
ISI
SICI code
0031-7144(199905)54:5<359:SAIAON>2.0.ZU;2-P
Abstract
5-Amino3-methylisoxazole-4-carboxylic acid amides and ureilenes have been s ynthesized from 5-amino-3-methylisoxazole-4-carbonyl azide. The compounds w ere investigated for potential immunotropic activity in several immunologic al tests. The most interesting suppressory activities in the humoral and ce llular immune response were compared to activities of analogous compounds p reviously described as immunostimulatory.