Fire-diffuse-fire model of dynamics of intracellular calcium waves

Authors
Dawson, SP Keizer, J Pearson, JE
Citation
Sp. Dawson et al., Fire-diffuse-fire model of dynamics of intracellular calcium waves, P NAS US, 96(11), 1999, pp. 6060-6063
Citations number
28
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
96
Issue
11
Year of publication
1999
Pages
6060 - 6063
Database
ISI
SICI code
0027-8424(19990525)96:11<6060:FMODOI>2.0.ZU;2-I
Abstract
When Ca2+ is released from internal stores in living cells, the resulting w ave of increased concentration can travel without deformation (continuous p ropagation) or with burst-like behavior (saltatory propagation). We analyze the "fire-diffuse-fire'' model in order to illuminate the differences betw een these two modes of propagation. We show that the Ca2+ release wave in i mmature Xenopus oocytes and cardiac myocytes is saltatory, whereas the fert ilization wave in the mature oocyte is continuous.