A 23-year-old female patient treated with 900 mg oxcarbazepine for complex
partial seizures is presented. Good seizure control and slight fever were n
oted a few weeks after drug administration. Reduction of oxcarbazepine and
replacement with valproate resulted in a transient normothermia. Because of
fever reappearance, vigabatrin was added and valproate was gradually reduc
ed. Seizures reappeared, but the body temperature fell below 37 degrees C.
Substitution of valproate for Iamotrigine resulted in seizure control but a
bnormal body temperature (37-37.6 degrees C) was noted again. Repeated hosp
ital admission for clinical and laboratory investigation before any change
of treatment revealed no other abnormal findings. The patient's abnormal te
mperature possibly reflects a derangement of high-level temperature control
.